MR volumetry in detection of brain atrophic changes in MS patients and its implication on disease prognosis: retrospective study

Abstract Background Multiple sclerosis is a chronic demyelinating disease of the central nervous system. It may lead to disability and cognitive impairment. Our study aimed at evaluation role MR volumetry technique in detection brain atrophic changes patients with multiple its impact on prognosis. Results This was carried out thirty healthy control mean age 26.23 years remitting relapsing sclerosis, 28.18 years. Patients were distributed across six subgroups based z -score cut-off − 1.96 for regional whole atrophy. We found that 2 (6.6%) showed no thalamic or atrophy, 28 (93.3%) atrophy only 10 (33.3%) both, BP No atrohy, 4 other structure rather than thalamus (13.3%), more one (33.3%). Relation between degree increase Expanded Disability Status Scale (EDSS) as well presence decline assessed. significant relation RRMS subgroup isolated EDSS decline. Conclusion MRI very useful assessment occur consequence affecting brain, deep grey matter corpus callosum. Although our did not prove impairment, warrants careful clinical those detect any possible further progression